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Larionova Marina
Date of birth 03-26-1991
Address 660036, Akademgorodok
50/50, Krasnoyarsk, Russia
E-mail larionova.marina@inbox.ru
EDUCATIONAL BACKGROUND
2014 – 2018 PhD in Biophysics
Siberian Federal University, Institute of Fundamental Biology and Biotechnology, Institute of Biophysics of Federal Research Center “Krasnoyarsk Science Center”, SB RAS
2012 – 2014 Master’s degree in Biotechnology
Siberian Federal University, Institute of Fundamental Biology and Biotechnology, Russia
PhD thesis “The novel luciferase isoforms from copepod Metridia longa: properties and application” (2018)
WORKING EXPERIENCE
2020 – present Researcher
Photobiology laboratory, Institute of Biophysics of Federal Research Center “Krasnoyarsk Science Center” SB RAS
2019 – 2020 Postdoc
Liu Zhi-Jie Laboratory, Molecular Imaging Department, “iHuman” institute, ShanghaiTech University, Chinese Academy of Sciences
2015 – 2019 Engineer-researcher
Photobiology laboratory, Institute of Biophysics of Federal Research Center “Krasnoyarsk Science Center” SB RAS
2011 – 2015 Laboratory assistant
Photobiology Laboratory, Institute of Biophysics of Federal Research Center “Krasnoyarsk Science Center” SB RAS
AWARDS AND GRANTS
2014 National scholarship for achievements in the field of biological and agricultural sciences, Krasnoyarsk Government, Russia
2016 Research grant “Development of application of Metridia luciferase in bioluminescent immunoassay” (Innovation Promotion Foundation, N 0019849)
2017 Award of Nobel laureate Shimomura’s Fund for achievements in the study of bioluminescence, Siberian Federal University, Russia
2018 National award for achievements in the field of professional education, Krasnoyarsk Government, Russia
2018 Diploma for the best scientific report, conference "Lomonosov-2018", Moscow
2020 Research grant “Development of bioluminescent sensors based on the Metridia luciferase for detection of protein-protein interactions” (RSF, project No. 21-74-00027).
CONFERENCES AND COURSES ATTENDED
2014 2nd International imaging workshop on modern methods of microscopy, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
2016 XXVII Winter science school on Physical and chemical biology and biotechnology, Moscow, Russia
2017 North-Biotech-Young winter science school, Northern Arctic Federal University, Arkhangelsk, Russia
2017 12th International scientific conference on bioorganic chemistry, Moscow, Russia
2018 “Lomonosov-2018” conference, Moscow State University, Moscow, Russia
2018 18th Young Scientists Forum FEBS, Prague, Czech Republic
2019 XFEL User’s meeting, Hamburg, Germany
2019 “From data collection to structure refinement and beyond”, CCP4/Shanghai school in macromolecular crystallography, Shanghai, China
2021 IX Congress of the Russian Photobiology Society, Shepsi, Russia
PATENTS
Mutant copepod luciferase for the application as an in vivo and in vitro bioluminescent reporter. Markova S.V., Dmitrieva D.A., Larionova M.D., Vysotski E.S. (2021) N 2757736.
PUBLICATIONS IN PEER REVIEWED JOURNALS
Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139 (2022) Zhou Y., Daver H., Trapkov B., Wu L., Wu M., Harpsшe K., Gentry P.R., Liu K., Larionova M., Liu J., Chen N., Brдuner-Osborne H., Gloriam D.E., Hua T., Liu Z.J. Cell Res. 32(2):210-213.
Crystal structure of semisynthetic obelin-v (2022) Larionova M.D., Wu L., Eremeeva E.V., Natashin P.V., Gulnov D.V., Nemtseva E.V., Liu D., Liu Z.J., Vysotski E.S. Protein Sci. 31(2):454-469.
The smallest isoform of Metridia longa luciferase as a fusion partner for hybrid proteins (2020) Larionova, M.D., Markova S.V., Tikunova N.V., Vysotski E.S. Int. J. Mol. Sci. 21:4971.
Shining light on the secreted luciferases of marine copepods: current knowledge and applications (2019) Markova S.V., Larionova, M.D., Vysotski E.S. Photochem Photobiol. 2019. 95:705-721.
Bioluminescent and structural features of native folded Gaussia luciferase (2018) M.D. Larionova, S.V. Markova, E.S. Vysotski. J Photochem Photobiol, B, 183, 309-317.
The disulfide-rich Metridia luciferase refolded from E. coli inclusion bodies reveals the properties of a native folded enzyme produced in insect cells (2017) S.V. Markova, M.D. Larionova, D.A. Gorbunova, E.S. Vysotski. J Photochem Photobiol, B, 175, 51-57.
The novel extremely psychrophilic luciferase from Metridia longa: properties of a high-purity protein produced in insect cells (2017) M.D. Larionova, S.V. Markova, E.S. Vysotski. Biochem Biophys Res Commun. 483 (1), 772-778.
Tyr72 and Tyr80 are involved in the formation of an active site of a luciferase of copepod Metridia longa (2017) M.D. Larionova, S.V. Markova, E.S. Vysotski. Photochem Photobiol. 93, 503-510.
The smallest natural high-active luciferase: cloning and characterization of novel 16.5-kDa luciferase from copepod Metridia longa (2015) S.V. Markova, M.D. Larionova, L.P. Burakova, E.S. Vysotski. Biochem Biophys Res Commun. 457, 77-82.
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