Natalja S. Rodionova, Ph.D

CURRICULUM VITAE

Academic Education:

• 1977–1982 – Student, Krasnoyarsk State University, Department of Biology and Chemistry, Krasnoyarsk, USSR

• 1986–1989 – Post-graduate student, Photobiology Laboratory, Institute of Biophysics, Russian Academy of Sciences, Siberian Branch, Krasnoyarsk, USSR

Scientific Degrees:

• 1982 – M.Sc., Biochemistry and Physiology of Human and Animals, Krasnoyarsk State University, Department of Biology and Chemistry, Krasnoyarsk, USSR

• 2004 – Ph.D., Biophysics. Thesis: “Bioluminescent systems of soil enchytraeids (Annelida:Clitellata:Oligochaeta:Enchytraeidae)”, Institute of Biophysics, Russian Academy of Sciences, Siberian Branch, Krasnoyarsk, Russia

Employment:

• 1982–2009 – Senior Laboratory Assistant, Trainee Researcher, Junior Researcher, Engineer, Photobiology Laboratory, Institute of Biophysics, Russian Academy of Sciences, Siberian Branch, Krasnoyarsk, Russia

• 2009–present – Researcher, Photobiology Laboratory, IBP SB RAS, Krasnoyarsk, Russia Siberian Branch, Krasnoyarsk, Russia

• 2009–present– Senior Researcher, Laboratory Ethnogenetic and Metabolic Problems in Norm and Pathology, Research Institute of Medical Problems of the North, Russian Academy of Medical Sciences, Siberian Branch, Krasnoyarsk, Russia

• 2011–present: Researcher, grant 1 11.G34.31.0058, Siberian Federal University, Krasnoyarsk, Russia.

Research Interests: bioluminescence, luminescent organisms, luminescent systems of earthworms, luciferases and luciferins, bioluminescent analysis

Grant Support:

Active:

• 2015-2018 – Russian Science Foundation (grant 16-14-00052) "Расшифровка молекулярного механизма биолюминесценции высших грибов и разработка методических основ ее использования с целью создания новой патентно чистой линии аналитических методов для биотехнологии и медицины" Investigator.

Completed:

• 2015-2017 – Russian Fund of Fundamental Investigation (RFFI 15-04-04414 A) “Isolation, studying of properties and structure elucidation of a substrate of luminescent reaction of luminous fungus Neonothopanus nambi.” Investigator.

• 2015-2017 – Russian Fund of Fundamental Investigation (RFFI 15-04-02695 A) “The novel сalcium-dependent luminescent system of soil enchytraeid Henlea sp.” Investigator.

Patents:

• Patent RF 2596398. Method and agents for detecting luciferase activity. I.V.Yampol"skiy, V.N.Petushkov, K.V.Purtov, N.S.Rodionova, M.S.Baranov. Published on September 10, 2016.

• Patent US 20180163248. Method and agents for detecting luciferase activity. I.V.Yampol"skiy, V.N.Petushkov, K.V.Purtov, N.S.Rodionova, M.S.Baranov. Published on June 14, 2018.

Publications in the last five years:

1. V.N.Petushkov, A.S.Tsarkova, M.A.Dubinnyi, N.S.Rodionova, S.M.Marques, J.C.Esteves da Silva, O.Shimomura, I.V.Yampolsky. CompX, a luciferin-related tyrosine derivative from the bioluminescent earthworm Fridericia heliota. Structure elucidation and total synthesis. Tetrahedron Letters. (2014) 55: 460-462.

2. V.N.Petushkov, A.S.Dubinnyi, N.S.Rodionova, K.D.Nadezhdin, S.M.Marques, J.C.Esteves da Silva, O.Shimomura, I.V.Yampolsky. AsLn2, a luciferin-related modified tripeptide from the bioluminescent earthworm Fridericia heliota. Tetrahedron Letters. (2014) 55: 463-465.

3. V.N.Petushkov, M.A.Dubinnyi, A.S.Tsarkova, N.S.Rodionova, M.S.Baranov, V.S.Kublitski, O.Shimomura, I.V.Yampolsky. A Novel Type of Luciferin from the Siberian Luminous Earthworm Fridericia heliota: Structure Elucidation by Spectral Studies and Total Synthesis. Angew. Chem. Int. Ed. Engl., (2014) 53(22): 5566–5568.

4. A.S.Tsarkova, M.A.Dubinnyi, M.S.Baranov, V.N.Petushkov, N.S.Rodionova, M.B.Zagudaylova, I.V.Yampolsky. Total synthesis of AsLn2 – a luciferin analogue from the Siberian bioluminescent earthworm Fridericia heliota. Mendeleev Commun. (2015) 25(2): 99-100.

5. M.A. Dubinnyi, A.S.Tsarkova, V.N.Petushkov, Z.M.Kaskova, N.S.Rodionova, S. I.Kovalchuk, R.H.Ziganshin, M.S.Baranov, K.S.Mineev, I.V.Yampolsky. Novel Peptide Chemistry in Terrestrial Animals: Natural Luciferin Analogues from the Bioluminescent Earthworm Fridericia heliota. Chemistry - A European Journal, (2015) 21(10): 3942-3947.

6. K.V.Purtov, V.N.Petushkov, M.S.Baranov, K.S.Mineev, N.S.Rodionova, Z.M.Kaskova, A.S.Tsarkova, A.I.Petunin, V.S.Bondar, E.K.Rodicheva, S.E.Medvedeva, Y.Oba, Y.Oba, A.S.Arseniev, S.Lukyanov, J.I.Gitelson, I.V.Yampolsky. The chemical basis of fungal bioluminescence. Angew. Chem. Int. Ed. Engl., (2015) 54(28): 8124–8128.

7. M.A.Dubinnyi, Z.M.Kaskova, N.S.Rodionova, M.S.Baranov, A.Yu.Gorokhovatsky, A.Kotlobai, K.M.Solntsev, A.S.Tsarkova, V.N.Petushkov, I.V.Yampolsky. Novel Mechanism of Bioluminescence: Oxidative Decarboxylation of a Moiety Adjacent to the Light Emitter of Fridericia Luciferin. Angew. Chem. Int. Ed. Engl., (2015) 54(24): 7065-7067.

8. Z.M.Kaskova, F.A.Dorr, V.N.Petushkov, K.V.Purtov, A.S.Tsarkova, N.S.Rodionova, K.S.Mineev, E.B.Guglya, A.Kotlobay, N.S. Baleeva, M.S.Baranov, A.S. Arseniev, J.I.Gitelson, S.Lukyanov, Y.Suzuki, S.Kanie, E.Pinto, P.Di Mascio, H.E.Waldenmaier, T.A.Pereira, R.P.Carvalho, A.G.Oliveira, Y.Oba, E.L.Bastos, C.V.Stevani, I.V.Yampolsky. Mechanism and Color Modulation of Fungal Bioluminescence. Science Advances. (2017) 3(4) e1602847 Published online. http://advances.sciencemag.org/content/3/4/e1602847.full

9. K.V.Purtov, V.N.Petushkov, N.S.Rodionova, J.I.Gitelson. Why Does the Bioluminescent Fungus Armillaria mellea Have Luminous Mycelium but Nonluminous Fruiting Body? Doklady Biochemistry and Biophysics. (2017) 474(1): 217–219.

10. K.V.Purtov, Z.M.Osipova, V.N.Petushkov, N.S.Rodionova, A.S.Tsarkova, A.A.Kotlobay, T.V.Chepurnykh, A.Yu.Gorokhovatsky, I.V.Yampolsky, J.I.Gitelson. Structure of fungal oxyluciferin, the product of the bioluminescence reaction. Doklady Biochemistry and Biophysics. (2017) 477(1): 360-363.

11. E.Rota, S.Martinsson, C.Erseus, V.N. Petushkov, N.S.Rodionova, P.Omodeo. Green light to an integrative view of Microscolex phosphoreus (Duges, 1837) (Annelida: Clitellata: Acanthodrilidae). ZOOTAXA. (2018) 4496(1): 175-189.

12. K.V.Purtov, A.Yu.Gorokhovatsky, A.A.Kotlobay, Z.M.Osipova, V.N.Petushkov, N.S.Rodionova, A.S.Tsarkova, T.V.Chepurnykh, I.V.Yampolsky, J.I.Gitelson. Isolation and Purification of Fungal Luciferase from Neonothopanus nimbi. Doklady Biochemistry and Biophysics. (2018) 480(1): 177-180.

13. V.N.Petushkov, N.S.Rodionova. Low-Molecular-Weight Components of Luminescent Reaction of the Siberian Enchytraeid Henlea sp. Doklady Biochemistry and Biophysics. (2018) 481: 212–216.

14. A.Kotlobay, K.S.Sarkisyan, Yu.A.Mokrushina, M.Marcet-Houben, E.O.Serebrovskaya, N.M.Markina, L.Gonzalez Somermeyer, A.Y.Gorokhovatsky, A.Vvedensky, K.V.Purtov, V.N.Petushkov, N.S.Rodionova, T.V.Chepurnykh, L.I.Fakhranurova, E.B.Guglya, R.Ziganshin, A.S.Tsarkova, Z.M.Kaskova, V.Shender, M.Abakumov, T.Abakumova, I.S.Povolotskaya, F.M.Eroshkin, A.G.Zaraisky, A.S.Mishin, S.V.Dolgov, T.Yu.Mitiouchkina, E.P.Kopantzev, H.Waldenmaier, A.G.Oliveira, Y.Oba, E.Barsova, E.A.Bogdanova, T.Gabaldon, C.V.Stevani, S.Lukyanov, I.V.Smirnov, J.I.Gitelson, F.A.Kondrashov, I.V.Yampolsky. A genetically encodable bioluminescent system from fungi. PNAS (2018) 115(49):